Comprehensive Single-Cell Atlas of Human Teeth

To far, medical and dental research has attracted a significant number of scientists and practitioners interested in combining genetics with tissue regeneration to address issues of great medical importance. Researchers in medicine and dentistry now have fresh insights on how to enhance clinical practice, thanks to advances in stem cell and tissue engineering. The question: How can we assist damaged tissues and organs heal? is one that many research organizations are tackling. Is it possible to grow back tissue that has been lost? To what extent can we standardize our stem cell treatment procedures across different types of therapies? ETH Zurich and the University of Zurich’s Institute of Oral Biology are working along with Thimios Mitsiadis, professor in the Department of Biosystems Science and Engineering, to develop the first-ever single-cell atlas for human teeth. Dr. Andreas Moor will lead the project. They were able to identify every single dental pulp and periodontium cell utilizing cutting-edge single-cell sequencing techniques. “These two tissues are vulnerable to tooth-specific and bacterially-linked diseases including caries and periodontitis, and our research gives us a unique knowledge of their composition for the first time. The periodontium and tooth pulp both contain stem cells with a high capacity for regeneration “senior researcher Pierfrancesco Pagella, a co-author on the paper, says:

The tooth pulp and periodontium were shown to have significant cellular heterogeneity, according to the results of the research. Interestingly, the molecular fingerprints of different stem cell groups were discovered to be very similar, which surprised the researchers. Pagella speculates that the differences in their behavior may be due to their unique habitat. Studies have shown a link between stem cell functional variations in different tooth compartments and microenvironmental uniqueness. To better comprehend human dental tissue’s cellular and molecular identity, this research shows how complicated dental tissues are. “Dental pulp and periodontal cells cooperate in immune responses to bacterial assaults, and single-cell methods may help us understand that interaction better. As a result, single-cell analysis may be helpful for diagnosing tooth problems early on “Thimios Mitsiadis, the last author, says. As a result, the results offer up new treatment options based on dental cells. This progress, says Mitsiadis, may lead to better treatments, effective regeneration of damaged teeth and even more accurate diagnostic tools for dental diseases in the future, he says As a result of the marriage of bioinformatics with contemporary dentistry, he says, many new developments have emerged.

University of Zurich. (2021, April 27). Comprehensive single-cell atlas of human teeth. ScienceDaily. Retrieved October 4, 2021 from

Categories: Dental