New anti-cancer treatment for gastric cancer using Ferroptosis

Korean researchers have suggested a new anti-cancer treatment for incurable stomach cancer. Ferroptosis is a method of treatment which applies to cancer cells with a new concept of apoptosis. This research is expected to help open up a new chapter in the treatment of incurable cancer in the future. The results of joint research by Dr. Lee Sang-chul and Dr. Lee Eun-woo of the Center for Transcription Control, Dr. Hwang Geum-research sook’s team, and Professor Heo Yong-min of Yonsei University Medical School were announced on the 13th by the Korea Institute of Biotechnology.

Ferroptosis, noted by the research team, is an iron-dependent necrosis caused by the cell membrane’s lipid peroxidation. As an important cell death pathway for the treatment of incurable cancer, which is immune to anti-cancer drugs, it attracts interest. Lipid peroxidation is the cause of cell death, such as the destruction of unsaturated fatty acids in the cell membrane by active oxygen. The team confirmed that only mesenchymal-types were killed by Ferroptosis drugs when the cell lines of the gastric canister were classified as mesenchymal-type and epigenial-type based on the transcriptional in patients with gastric canister. The research team analyzed that the result was due to the fact that the gene (ELOVL5, FADS1) discovered in the study was essential for the formation of the core phosphorus of ferroptosis progression in the mesenchymal type gas canister cell line. These genes create an environment in which lipid peroxidation can occur, resulting in the extinction of mesophyllous gastric cancer cells.

Mesenchymal-type gastric caner is known to have the worst prognosis, such as easily transferred or resistant to existing anti-cancer drugs. The five-year survival rate is less than 30 percent. A mesenchymal cell is a type of stem cell that is differentiated by the cleavage of fertilized eggs. It can be self-replicated or differentiated into various cells.

Professor Heo Yong-min said, “The incurable disease treatment that will be developed through this research result will be effective in incurable gastric cancer, which cannot be prevented from recurrence by existing standard anti-cancer drugs.”


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