Clinical

Auditory hallucinations rooted in aberrant brain connectivity

Symptoms of schizophrenia can be the result of increased interactions between the brain regions of sensory and language processing.

Auditory hallucinations are a hallmark of schizophrenia and certain other neuropsychiatric conditions, a condition in which people hear voices or other noises in the absence of external stimuli. It has been unclear how they occur in the brain, but recent research suggests that it could be responsible for altered brain integration between sensory and cognitive processing areas. Schizophrenia and hallucinations have also been involved in disturbances in the thalamus, a brain area known as the “gateway” for sensory input coming into the brain.

source : https://www.sciencedaily.com/releases/2020/06/200630111442.htm

Most study on the genetics of schizophrenia has attempted to understand the role genes play in schizophrenia’s development and heritability. Many findings were made, but there were a lot of parts missing. To provide a more detailed image of the role of the human genome in this disorder, scientists have performed the largest-ever complete genome sequencing analysis of schizophrenia. In detrimental forms that could lead to congenital abnormalities, cancer growth, and developmental disorders, gene expression may be modified. This research showed that in persons with schizophrenia, exceedingly unusual structural variants affecting TAD boundaries in the brain occur substantially more frequently than in people without it.

Large mutations that may include incomplete or duplicated genetic sequences, or sequences that are not in the normal genome, are structural variants. This finding indicates that misplaced or incomplete limits of TAD can also lead to schizophrenia development.

Source : https://www.sciencedaily.com/releases/2020/04/200416151704.htm

A molecular switch has the potential to turn on an animal material that restores neurological damage in diseases such as multiple sclerosis (MS), researchers from the Mayo Clinic have found. An already licensed Food and Drug Administration therapy could advance early research in animal models and could also lead to new methods for the treatment of central nervous system diseases. Myelin functions like a wire insulator that protects the electrical signals that are transmitted through the nervous system. Demyelination, or myelin damage, delays electrical signals between cells of the brain, resulting in sensory and motor function loss. The harm is permanent sometimes. In diseases such as MS, Alzheimer’s disease, Huntington’s disease, schizophrenia and spinal cord injury, demyelination is observed. Thrombin is a blood protein that assists in healing. Too much thrombin, however, activates the PAR1 receptor located on the cell surface, and this inhibits the production of myelin. In multiple sclerosis, oligodendrocyte progenitor cells capable of myelin regeneration are frequently located at myelin injury sites, including demyelinating injuries.

Categories: Clinical, Mental Health